BR351

性能参数

产品名称

BR351

规格

250mg 500mg

货号

GOY-Y0745

 含量

>98.00%

CAS

960113-85-3

别名

N/A

化学名

N/A

分子式

C20H25FN2O5S

分子量

分子 424.49

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].

[18F]BR351 Is quickly metabolized in plasma with 20.28% ± 5.41% of intact tracer remaining at 15 minutes postinjection[2].

[1]. Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. [2]. Vazquez N, et al. Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer. J Labelled Comp Radiopharm. 2017 Jan;60(1):69-79.

Kushenol A CS-01Y64251 1mg 5mg >98.00% 99217-63-7

KU-32 CS-01Y64252 250mg 500mg >98.00% 956498-70-7

L-Dihydroorotic acid CS-01Y64253 100mg 500mg >98.00% 5988-19-2

L-Cystathionine CS-01Y64254 10mM*1mLinDMSO 5mg >98.00% 56-88-2

L-Carnitine inner salt CS-01Yጪ

基膦酰基乙酸酯Trimethyl phosphonoacetate,98%5927-18-425G

庚酸烯丙酯Allyl heptanoate,≥97%142-19-825G

己酸烯丙酯Allyl hexanoate,≥98%123-68-2100G

原丁酸酯Trimethyl orthobutyrate,≥97.0%43083-12-15ML

原戊酸methyl orthovalerate,≥97.0%13820-09-25ML

三氟乙酸丙烯酯Allyltrifluoroacetate,98%383-67-510G